M0880

Ethyl methanesulfonate

liquid

• Synonyme(s) : Ethyl mesylate, Methanesulfonic acid ethyl ester
• Formule linéaire : CH₃SO₃CH₂CH₃
• CAS Number: 62-50-0
• Poids moléculaire : 124.16
• Beilstein: 773969
• Numéro CE : 200-536-7
• Numéro MDL: MFCD00007559
• Code UNSPSC : 12352108
• ID de substance PubChem : 24896575
• Nomenclature NACRES : NA.25

Propriétés

• Forme: liquid
• Niveau de qualité: 200
• Indice de réfraction: n20/D 1.418 (lit.)
• pb: 85-86 °C/10 mmHg (lit.)
• Densité: 1.206 g/mL at 20 °C
• Chaîne SMILES: CCOS(C)(=O)=O
• InChI: 1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3
• Clé InChI: PLUBXMRUUVWRLT-UHFFFAOYSA-N

Description

Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Actions biochimiques/physiologiques

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H317,H319,H340,H350,H361f
• Conseils de prudence: P202 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 212.0 °F
• Point d'éclair (°C): 100 °C
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter