N8509

N-Nitroso-N-ethylurea

Bulk package

• Synonyme(s) : ENU, N-Ethyl-N-nitrosourea
• Formule empirique (notation de Hill) : C₃H₇N₃O₂
• CAS Number: 759-73-9
• Poids moléculaire : 117.11
• Numéro CE : 212-072-2
• Numéro MDL: MFCD00053635
• Code UNSPSC : 12352102
• ID de substance PubChem : 24897681
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Forme: powder
• Contient: aqueous acetic acid as stabilizer
• Température de stockage: −20°C
• Chaîne SMILES: CCN(N=O)C(N)=O
• InChI: 1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)
• Clé InChI: FUSGACRLAFQQRL-UHFFFAOYSA-N

Description

Application

• Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.: This study identifies genetic factors affecting blood pressure and heart rate using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis. The research utilizes automated meiotic mapping to reveal the genetic underpinnings of these cardiovascular traits, providing insights that could inform therapeutic targets (Teixeira et al., 2024).


• Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea.: This study examines the effects of ENU on T lymphocyte clonality and trafficking in mice. The findings provide insights into the mutagenic and immunological impacts of ENU, contributing to our understanding of chemical-induced mutations (Judice et al., 2023).


• Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.: This proof-of-concept study integrates duplex sequencing technology to test genetic toxicity in rats exposed to ENU. The results demonstrate the feasibility and effectiveness of this approach in detecting mutagenic effects, highlighting its potential for genetic toxicity assessment (Smith-Roe et al., 2023).

Actions biochimiques/physiologiques

DNA alkylating agent that is carcinogenic in many animal species. Induces benign and malignant tumors of numerous types, including the nervous tissue, stomach, esophagus, pancreas, respiratory tract, intestine, lymphoreticular tissues, skin, and kidney.

Conditionnement

Weight on dry basis.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H312 + H332,H350,H360
• Conseils de prudence: P202 - P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
• Classification des risques: Acute Tox. 3 Oral - Carc. 1B - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges