M1508

4-Methylumbelliferone sodium salt

fluorogenic, ≥98% (HPLC), crystalline

• Synonyme(s) : β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
• Formule linéaire : C₁₀H₇O₃Na
• CAS Number: 5980-33-6
• Poids moléculaire : 198.15
• Numéro CE : 227-790-1
• Numéro MDL: MFCD00069856
• Code UNSPSC : 12352204
• ID de substance PubChem : 24896658
• Nomenclature NACRES : NA.32

Propriétés

• Product Name: 4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: crystalline
• Couleur: yellow
• Solubilité: water: 50 mg/mL
• Chaîne SMILES: [Na+].CC1=CC(=O)Oc2cc([O-])ccc12
• InChI: 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
• Clé InChI: JGMQHDNPUCPRQE-UHFFFAOYSA-M

Description

Description générale

4-methylumbelliferone (4-MU) is a coumarin derivative.

Application

4-Methylumbelliferone sodium salt has been used:

• as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
• as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
• in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer

Actions biochimiques/physiologiques

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)