M2949

MDL 72527

≥98% (HPLC)

• Synonyme(s) : CPC-200, MDL-72527DA, N,N′-Bis(2,3-butadienyl)-1,4-butanediamine dihydrochloride, N1,N4-Bis(2,3-butadienyl)-1,4-butanediamine hydrochloride
• Formule empirique (notation de Hill) : C₁₂ H₂₀ N₂·2 HCl
• CAS Number: 93565-01-6
• Poids moléculaire : 265.22
• Numéro MDL: MFCD13152261
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817958
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to brown
• Solubilité: H₂O: 15 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: Cl.Cl.C=C=CCNCCCCNCC=C=C
• InChI: 1S/C12H20N2.2ClH/c1-3-5-9-13-11-7-8-12-14-10-6-4-2;;/h5-6,13-14H,1-2,7-12H2;2*1H
• Clé InChI: ITVRWVVFVHINOH-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO).

MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable