M4267

Mefenamic acid

• Synonyme(s) : 2-[(2,3-Dimethylphenyl)amino]benzoic acid, N-(2,3-Xylyl)anthranilic acid
• Formule empirique (notation de Hill) : C₁₅H₁₅NO₂
• CAS Number: 61-68-7
• Poids moléculaire : 241.29
• Numéro CE : 200-513-1
• Numéro MDL: MFCD00051721
• Code UNSPSC : 12161501
• ID de substance PubChem : 24896815
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Auteur: Shionogi
• Chaîne SMILES: Cc1cccc(Nc2ccccc2C(O)=O)c1C
• InChI: 1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
• Clé InChI: HYYBABOKPJLUIN-UHFFFAOYSA-N
• Informations sur le gène: human ... PTGS1(5742), PTGS2(5743)

Description

Application

An NSAID. Circumvents MRP-mediated multidrug resistance. Specifically and significantly potentiates the cytotoxicity of anthracyclines as well as teniposide, VP-16 and vincristine.

Mefenamic acid has been used:

• to test its hepatotoxic effect in the transgenic zebrafish cell line (LiPan)
• to test its neuroprotective functionality in zebrafish embryos/larvae
• in the preparation of mucoadhesive microparticles in hydrogel beads

Actions biochimiques/physiologiques

Mefenamic acid is an analgesic and anti-inflammatory drug. It acts as a cyclooxygenase (COX) enzyme inhibitor. It is hepatoxic and implicated in liver injury. Contrarily, mefenamic acid elicits neuroprotection in in vivo ischemic stroke models by inhibiting cell toxicity induced by glutamate. Mefenamic due its inhibitory effect on prostaglandin synthesis can be used in reducing edema and ache.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves