M5269

Moniliformin sodium salt from Fusarium proliferatum

• Synonyme(s) : 1-Hydroxycyclobut-1-ene-3,4-dione
• Formule linéaire : C₄HO₃Na
• CAS Number: 71376-34-6
• Poids moléculaire : 120.04
• Numéro MDL: MFCD00056566
• Code UNSPSC : 12352200
• ID de substance PubChem : 24896991
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1C(C=C1[O-])=O.[Na+]
• InChI: 1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
• Clé InChI: FERDNJVXTWPNSA-UHFFFAOYSA-M

Description

Description générale

Moniliformin (MON), a mycotoxin and small ionic molecule, is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum. It is present as sodium or potassium salt of semisquaric acid naturally. MON is also present in maize and small-grain cereals.

Application

Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard:

• to test its acute oral toxicity in mice
• to test its subacute toxic effects in rats
• in characterizing mycotoxins from Aspergillus

Actions biochimiques/physiologiques

Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats. It inhibits the tricarboxylic acid (TCA) cycle oxidation step. By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway. ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P310
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges