M6635

N-(2-Mercaptopropionyl)glycine

• Synonyme(s) : Tiopronine
• Formule linéaire : CH₃CH(SH)CONHCH₂COOH
• CAS Number: 1953-02-2
• Poids moléculaire : 163.19
• Beilstein: 1859822
• Numéro CE : 217-778-4
• Numéro MDL: MFCD00004861
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 24897101
• Nomenclature NACRES : NA.26

Propriétés

• Essai: ≥98% (TLC)
• Niveau de qualité: 100
• Forme: powder
• Couleur: white
• Pf: 98-100 °C
• Application(s): cell analysis; peptide synthesis
• Chaîne SMILES: CC(S)C(=O)NCC(O)=O
• InChI: 1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
• Clé InChI: YTGJWQPHMWSCST-UHFFFAOYSA-N

Description

Application

N-(2-Mercaptopropionyl)glycine or Tiopronin has been used:

• in the preparation of polyethylenimine (PEI)-coated gold microparticles (PEI-gold) for biolistic delivery of nucleic acids
• to study the role of reactive oxygen species (ROS) at the reperfusion stage in in vivo isoflurane preconditioning-induced neuroprotection
• as a ROS inhibitor to study its effect on lysophosphatidylcholine (LPC)-induced inflammasome activation

Actions biochimiques/physiologiques

N-(2-Mercaptopropionyl)glycine (NMPG) is a thiol compound associated with autoimmune hypoglycemia. It is a diffusible antioxidant and reduces the severity of colonic injury. NMPG also relieves myeloperoxidase activity and stimulates hypoxia-inducible factor-1 (HIF-1) - vascular endothelial growth factor (VEGF) pathway for ulcer healing.

N-(2-Mercaptopropionyl)glycine is a free radical scavenger.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves