M6545

Mitoxantrone dihydrochloride

≥97% (HPLC)

• Synonyme(s) : 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride
• Formule empirique (notation de Hill) : C₂₂H₂₈N₄O₆ · 2HCl
• CAS Number: 70476-82-3
• Poids moléculaire : 517.40
• Numéro CE : 274-619-1
• Numéro MDL: MFCD00242943
• Code UNSPSC : 12352005
• ID de substance PubChem : 24278562
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Chaîne SMILES: Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
• InChI: 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
• Clé InChI: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
• Informations sur le gène: human ... TOP2A(7153)

Description

Application

Mitoxantrone dihydrochloride has been used:

• to induce calreticulin surface expression in cells
• as a genotoxin agent
• as a topoisomerase inhibitor

Actions biochimiques/physiologiques

Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H340,H360
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Muta. 1B - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges