P0043

PNU-120596

≥98% (HPLC)

• Synonyme(s) : N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea, NSC 216666
• Formule empirique (notation de Hill) : C₁₃H₁₄ClN₃O₄
• CAS Number: 501925-31-1
• Poids moléculaire : 311.72
• Numéro MDL: MFCD00095313
• Code UNSPSC : 12352200
• ID de substance PubChem : 329819995
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: O=C(NC1=NOC(C)=C1)NC2=CC(Cl)=C(OC)C=C2OC
• InChI: 1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
• Clé InChI: CEIIEALEIHQDBX-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.

PNU-120596 is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable