P2116

Pirfenidone

≥97% (HPLC), powder, antifibrotic agent

• Synonyme(s) : 5-Methyl-1-phenyl-2-(1H)-pyridone
• Formule empirique (notation de Hill) : C₁₂H₁₁NO
• CAS Number: 53179-13-8
• Poids moléculaire : 185.22
• Numéro MDL: MFCD00866047
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278625
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Pirfenidone, ≥97% (HPLC)
• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: powder
• Solubilité: H₂O: >10 mg/mL at 60 °C (warming for 30 minutes); DMSO: >20 mg/mL
• Auteur: Shionogi
• Chaîne SMILES: O=C(C=CC(C)=C1)N1C2=CC=CC=C2
• InChI: 1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
• Clé InChI: ISWRGOKTTBVCFA-UHFFFAOYSA-N

Description

Description générale

Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.

Application

Pirfenidone has been used:

• as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery
• as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit
• to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)
• as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia

Actions biochimiques/physiologiques

Inhibits collagen production and fibroblast proliferation.

Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts.

Caractéristiques et avantages

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves