P7136

Pyrazinecarboxamide

• Synonyme(s) : Pyrazinamide, Pyrazinoic acid amide
• Formule empirique (notation de Hill) : C₅H₅N₃O
• CAS Number: 98-96-4
• Poids moléculaire : 123.11
• Beilstein: 112306
• Numéro CE : 202-717-6
• Numéro MDL: MFCD00006132
• Code UNSPSC : 41116107
• ID de substance PubChem : 24278648
• Nomenclature NACRES : NA.85

Propriétés

• Forme: powder
• Niveau de qualité: 200
• Pf: 189-191 °C (lit.)
• Spectre d'activité de l'antibiotique: mycobacteria
• Mode d’action: cell membrane | interferes
• Chaîne SMILES: NC(=O)c1cnccn1
• InChI: 1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
• Clé InChI: IPEHBUMCGVEMRF-UHFFFAOYSA-N

Description

Application

Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .

Actions biochimiques/physiologiques

The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)