P7762

Poly-L-arginine hydrochloride

mol wt 15,000-70,000

• Synonyme(s) : L-Arginine homopolymer hydrochloride
• CAS Number: 26982-20-7
• Numéro MDL: MFCD00166393
• Code UNSPSC : 12352209
• ID de substance PubChem : 24898874
• Nomenclature NACRES : NA.26

Propriétés

• Forme: powder
• Niveau de qualité: 200
• Poids mol.: 15,000-70,000
• Couleur: white to off-white
• Application(s): cell analysis
• Température de stockage: −20°C
• Chaîne SMILES: Cl.NC(CCCNC(N)=N)C(O)=O
• InChI: 1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1
• Clé InChI: PQEISBBDIRAKGR-LFELFHSZSA-N

Description

Description générale

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Application

Poly-L-arginine hydrochloride has been used:

• to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
• used in ribosomal RNA transfection into human monocytic THP-1 cells
• for coating alginate capsule beads

Qualité

Contains 3% or less ornithine residue.

Remarque sur l'analyse

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)