P7888

DL-Propargylglycine

cystathionine γ-lyase inhibitor

• Synonyme(s) : 2-Amino-4-pentynoic acid, PAG
• Formule empirique (notation de Hill) : C₅H₇NO₂
• CAS Number: 64165-64-6
• Poids moléculaire : 113.11
• Numéro MDL: MFCD00056728
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 24898885
• Nomenclature NACRES : NA.26

Propriétés

• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Couleur: white
• Application(s): cell analysis
• Température de stockage: −20°C
• Chaîne SMILES: NC(CC#C)C(O)=O
• InChI: 1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)
• Clé InChI: DGYHPLMPMRKMPD-UHFFFAOYSA-N

Description

Application

• Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy.: This study demonstrates the enhanced antibacterial efficiency of a metabolic labeling strategy using ᴅʟ-Propargylglycine in photothermal and photodynamic therapy for treating bacteria-infected wounds (Li et al., 2022).


• Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.: This research utilizes ᴅʟ-Propargylglycine for metabolic labeling, allowing near-infrared II imaging of gut microbiota in vivo, providing new insights into microbiome studies (Wang et al., 2020).


• Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats.: Investigates the role of ᴅʟ-Propargylglycine, in upregulating specific mRNA expressions in gastric mucosa, with implications for gastrointestinal research (Cheraghi et al., 2016).

Actions biochimiques/physiologiques

DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H₂S).

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves