P9248

PD 169316

≥98% (HPLC), solid

• Synonyme(s) : 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
• Formule empirique (notation de Hill) : C₂₀H₁₃FN₄O₂
• CAS Number: 152121-53-4
• Poids moléculaire : 360.34
• Numéro MDL: MFCD12405019
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278156
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: faint yellow to dark orange
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Auteur: GlaxoSmithKline
• Température de stockage: 2-8°C
• Chaîne SMILES: [O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• Clé InChI: BGIYKDUASORTBB-UHFFFAOYSA-N
• Informations sur le gène: human ... MAPK14(1432)

Description

Description générale

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Application

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Actions biochimiques/physiologiques

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Caractéristiques et avantages

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H318,H335
• Conseils de prudence: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classification des risques: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves