Q1250

Quinine hemisulfate salt monohydrate

synthetic, ≥90% (HPLC)

• Formule empirique (notation de Hill) : C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O
• CAS Number: 207671-44-1
• Poids moléculaire : 391.47
• Beilstein: 6113937
• Numéro MDL: MFCD00150790
• Code UNSPSC : 12352210
• ID de substance PubChem : 57654578
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥90% (HPLC)
• Pf: ~225 °C (dec.) (lit.)
• Solubilité: H₂O: slightly soluble 1.2 mg/mL; ethanol: 8 mg/mL
• Spectre d'activité de l'antibiotique: parasites
• Mode d’action: enzyme | inhibits
• Auteur: Bayer
• Chaîne SMILES: O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
• Clé InChI: ZHNFLHYOFXQIOW-LPYZJUEESA-N

Description

Application

Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.

Actions biochimiques/physiologiques

Potassium channel blocker. Antimalarial

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Quinine has analgesic property.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves