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RAB0018

Sigma-Aldrich

Apelin EIA Kit

for serum, plasma, culture supernatant and cell lysates

Synonyme(s) :

Apelin

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About This Item

Code UNSPSC :
12352204
Nomenclature NACRES :
NA.32
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Espèces réactives

rat, mouse, human

Conditionnement

kit of 96 wells (12 strips x 8 wells)

Technique(s)

ELISA: suitable
enzyme immunoassay: suitable

Entrée

sample type cell lysate
sample type plasma
sample type serum
sample type culture supernatant(s)

assay range

inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 5.84 pg/mL
standard curve range: 0.1-1000 ng/mL

Méthode de détection

colorimetric

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... APLN(8862)

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1 of 4

Cet article
B1901I3400K1632
assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (SDS-PAGE)

assay

-

form

powder

form

powder

form

lyophilized powder

form

lyophilized powder

Gene Information

human ... KNG1 (includes EG:3827)(3827)

Gene Information

human ... KNG1 (includes EG:3827)(3827)

Gene Information

human ... CXCL10(3627)

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P01042

UniProt accession no.

P01042

UniProt accession no.

P01579

UniProt accession no.

P01042

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

Description générale

The Apelin C-Terminus Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting Apelin C-Terminus peptide based on the principle of Competitive Enzyme Immunoassay. The EIA-APC-1 kit detects all active Apelin peptides, including Apelin-13, Apelin-28, Apelin-31 and Apelin-36.

Immunogène

Apelin, synthetic peptide

Application

For research use only. Not for use in diagnostic procedures.
Apelin EIA kit has been used to determine the concentration of apelin in pre-adipocyte growth medium.[1]

Actions biochimiques/physiologiques

Apelin (APLN) is secreted by white adipose tissue. It is an adipokine which has a role in tumor cell progression and vascularization. The protein may have a role in obesity-related disorders. APLN is involved in modulating energy homeostasis, water balance, glucose metabolism and immunity. It has been shown to be upregulated in many cancers.[2][3][4][5]

Composants de kit également disponibles séparément

Réf. du produit
Description
FDS

Pictogrammes

Corrosion

Mention d'avertissement

Warning

Mentions de danger

Conseils de prudence

Classification des risques

Met. Corr. 1

Code de la classe de stockage

8A - Combustible corrosive hazardous materials


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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M T Nieman et al.
Journal of thrombosis and haemostasis : JTH, 6(5), 837-845 (2008-03-05)
Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin - RPPGF. These peptides are direct thrombin inhibitors prolonging the thrombin clotting time
Marvin T Nieman et al.
FEBS letters, 579(1), 25-29 (2004-12-29)
The angiotensin converting enzyme breakdown product of bradykinin, bradykinin 1-5 (RPPGF), inhibits thrombin-induced human or mouse platelet aggregation. RPPGF binds to the exodomain of human protease-activated receptor 1 (PAR1). Studies determined if RPPGF also binds to the exodomain of human
Mias Pretorius et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(11), 2435-2440 (2005-09-17)
Angiotensin-converting enzyme inhibition (ACEI) increases vascular tissue plasminogen activator (t-PA) release through endogenous bradykinin (BK). We tested the hypothesis that gender influences the effect of ACEI on t-PA release. We measured the effect of intra-arterial enalaprilat (0.33 microg/min per 100
Elizabeth A Girnys et al.
Bioorganic & medicinal chemistry, 19(24), 7425-7434 (2011-11-08)
The serine protease thrombin plays several key roles in the clotting cascade within the hemostatic system, such as in fibrin formation and platelet activation. Thus, development of an inhibitor that binds to the enzyme's active site (a direct thrombin inhibitor)
A A Hasan et al.
Thrombosis and haemostasis, 82(3), 1182-1187 (1999-09-24)
Thrombostatin (RPPGF), an angiotensin converting enzyme metabolite of bradykinin, is an inhibitor of alpha-thrombin's ability to activate platelets. We examined the in vivo pharmacokinetics and pharmacodynamics of thrombostatin in rabbits and its ability to inhibit coronary thrombosis induced by electrolytic

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