S3378

Spironolactone

97.0-103.0% (HPLC), powder, aldosterone receptor antagonist

• Synonyme(s) : 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate, 7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
• Formule empirique (notation de Hill) : C₂₄H₃₂O₄S
• CAS Number: 52-01-7
• Poids moléculaire : 416.57
• Numéro CE : 200-133-6
• Numéro MDL: MFCD00082250
• Code UNSPSC : 51111800
• ID de substance PubChem : 24277736
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Spironolactone, 97.0-103.0%
• Niveau de qualité: 200
• Essai: 97.0-103.0%
• Pf: 207-208 °C (lit.)
• Solubilité: chloroform: complete 50 mg/ml, clear, faintly yellow
• Chaîne SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13
• InChI: 1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
• Clé InChI: LXMSZDCAJNLERA-ZHYRCANASA-N
• Informations sur le gène: human ... HSD17B1(3292), NR3C2(4306) ; rat ... Ar(24208)

Description

Application

Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.

Actions biochimiques/physiologiques

Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.

Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis. It reduces hypertension, improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure. Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H351,H360FD,H373
• Conseils de prudence: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Carc. 2 - Repr. 1B - STOT RE 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges