C7287

Canrenoic acid potassium salt

powder

• Synonyme(s) : 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid, Potassium canrenoate
• Formule linéaire : C₂₂H₃₀O₄K
• CAS Number: 2181-04-6
• Poids moléculaire : 397.57
• Numéro CE : 218-554-9
• Numéro MDL: MFCD05662375
• Code UNSPSC : 12352106
• ID de substance PubChem : 24892953
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Couleur: light yellow to tan
• Chaîne SMILES: [K].[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)CCC(O)=O)[C@]1([H])C=CC4=CC(=O)CC[C@]24C
• InChI: 1S/C22H30O4.K.H/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);;/t16-,17+,18+,20+,21+,22-;;/m1../s1
• Clé InChI: YLXFIHIYNGPPSF-HUHWECDNSA-N

Description

Application

Canrenoic acid potassium salt has been used as a human uridine 5′-diphospho (UDP)-glucuronosyltransferase inhibitor to study its effects on trifluoperazine (TFP) substrate selectivity. It has also been used to study its effects on the formation of aldosterone 18-glucuronide (ALDO 18β-G) in recombinant UDP-Glucuronosyltransferase-2B7 (UGT2B7), human liver (HLM) and human kidney cortical (HKCM) microsomes.

Actions biochimiques/physiologiques

Competitive aldosterone receptor antagonist.

Competitive aldosterone receptor antagonist. Potassium canrenoate reduces the effects of aldosterone-induced increases in blood pressure and in cardiovascular fibrosis in animals with high sodium intake. It is used clinically for its anti-fibrotic effects. At higher doses it is genotoxic to liver and increases tumor incidence in rodent models.

Remarque sur l'analyse

Aqueous solutions may contain some insoluble material.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves