S3442

SB 216763

>98% (HPLC)

• Synonyme(s) : 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Formule empirique (notation de Hill) : C₁₉H₁₂N₂O₂Cl₂
• CAS Number: 280744-09-4
• Poids moléculaire : 371.22
• Numéro MDL: MFCD09753369
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278616
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: >98% (HPLC)
• Couleur: orange
• Solubilité: DMSO: soluble 20 mg/mL; H₂O: insoluble
• Auteur: GlaxoSmithKline
• Température de stockage: −20°C
• Chaîne SMILES: Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14
• InChI: 1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
• Clé InChI: JCSGFHVFHSKIJH-UHFFFAOYSA-N
• Informations sur le gène: human ... GSK3A(2931), GSK3B(2932)

Description

Application

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Actions biochimiques/physiologiques

Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

Sold for research purposes under agreement from Glaxo­Smith­Kline

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves