S3567

SB 415286

≥98% (HPLC)

• Synonyme(s) : 3-[(3-Chloro-4-hydroxyphenyl)­amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
• Formule empirique (notation de Hill) : C₁₆H₁₀N₃O₅Cl
• CAS Number: 264218-23-7
• Poids moléculaire : 359.72
• Numéro MDL: MFCD04039789
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278412
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Couleur: yellow to orange
• Solubilité: DMSO: 5 mg/mL, clear; H₂O: insoluble
• Auteur: GlaxoSmithKline
• Température de stockage: −20°C
• Chaîne SMILES: Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl
• InChI: 1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
• Clé InChI: PQCXVIPXISBFPN-UHFFFAOYSA-N
• Informations sur le gène: human ... GSK3A(2931), GSK3B(2932)

Description

Application

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

Actions biochimiques/physiologiques

Glycogen synthase kinase-3 (GSK-3) inhibitor.

SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents.

Caractéristiques et avantages

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

Sold for research purposes under agreement from GlaxoSmithKline.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves