S4069

SL327

≥98% (HPLC), Mixture of E & Z isomers, solid

• Synonyme(s) : α-[Amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile, SL 327, SL-327
• Formule empirique (notation de Hill) : C₁₆H₁₂F₃N₃S
• CAS Number: 305350-87-2
• Poids moléculaire : 335.35
• Numéro MDL: MFCD06411432
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824537
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated; protect from light
• Couleur: white to off-white
• Pf: 127-128.2 °C
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
• InChI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
• Clé InChI: JLOXTZFYJNCPIS-FYWRMAATSA-N

Description

Application

SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).

SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.

Actions biochimiques/physiologiques

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro.

SL327 is a selective MEK1/2inhibitor (IC₅₀ values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)