S7942

Sirtinol

≥95% (HPLC)

• Synonyme(s) : 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide
• Formule empirique (notation de Hill) : C₂₆H₂₂N₂O₂
• CAS Number: 410536-97-9
• Poids moléculaire : 394.47
• Numéro MDL: MFCD00810186
• Code UNSPSC : 12352203
• ID de substance PubChem : 24899771
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥95% (HPLC)
• Forme: solid
• Solubilité: DMSO: soluble
• Température de stockage: −20°C
• Chaîne SMILES: CC(NC(=O)c1ccccc1\N=C\c2c(O)ccc3ccccc23)c4ccccc4
• InChI: 1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+
• Clé InChI: UXJFDYIHRJGPFS-WPWMEQJKSA-N
• Informations sur le gène: human ... SIRT1(23411), SIRT2(22933)

Description

Application

HUVEC were treated with sirtinol to study the effect on induction of transcription factor Krüppel-like factor 2.⁴ Sirtinol was used to treat human embryonic kidney cells to study the effect on the expression on Werner syndrome protein.⁵

Actions biochimiques/physiologiques

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p and human SIRT2 deacetylase activity in vitro. It inhibits the physiological regulators of platelet aggregation such as thrombin and collagen, attenuates intracellular Ca²⁺ release and formation thromboxane B2. It may increase levels of cAMP by inhibition of cAMP phosphodiesterase and inhibit the aggregation of platelets.² Sirtinol reduces inflammatory responses of human dermal microvascular endothelial cells to TNF-α and IL-1β.³

Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p, and human SIRT2 deacetylase activity in vitro.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)