SML0003

CID755673

≥98% (HPLC), powder

• Synonyme(s) : 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one, 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one
• Formule empirique (notation de Hill) : C₁₂H₁₁NO₃
• CAS Number: 521937-07-5
• Poids moléculaire : 217.22
• Numéro MDL: MFCD03828155
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825080
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥15 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Oc1ccc2oc3C(=O)NCCCc3c2c1
• InChI: 1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)
• Clé InChI: AACFPJSJOWQNBN-UHFFFAOYSA-N

Description

Application

CID755673 was used to study the role of PKD in dendrite retraction in mouse Purkinje cells.

Actions biochimiques/physiologiques

CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1 (PKCμ), PKD2, and PKD3 (PKCν). CID755673 is not competitive with ATP.

CID755673 is a cell-permeable, potent and selective inhibitor of all three protein kinase D (PKD) isoforms PKD1(PKCμ), PKD2, and PKD3 (PKCν).

CID755673 was not suitable to inhibit PKD in Swiss 3T3 cells as it utilizes PKD-dependent pathway to enhance the mitogenic signaling triggered by EGF, phorbol esters and bombesin. It should, therefore, be used with caution.

Caractéristiques et avantages

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3