T1573

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

• Synonyme(s) : TRAP-6
• Formule empirique (notation de Hill) : C₃₄H₅₆N₁₀O₉
• CAS Number: 141136-83-6
• Poids moléculaire : 748.87
• Numéro MDL: MFCD00238172
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826680
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: >95% (HPLC)
• Forme: lyophilized
• Technique(s): cell culture | mammalian: suitable
• Solubilité: 0.1% TFA: soluble; water: soluble
• Numéro d'accès UniProt: P25116
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
• Clé InChI: HAGOWCONESKMDW-FRSCJGFNSA-N
• Informations sur le gène: human ... F2R(2149)

Description

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

Description générale

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Actions biochimiques/physiologiques

Hexapeptide fragment of the thrombin receptor (residues 42-47).

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC₅₀ = 0.8 μM).

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)