SML0033

Itopride hydrochloride

≥98% (HPLC)

• Synonyme(s) : N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
• Formule empirique (notation de Hill) : C₂₀H₂₆N₂O₄ ·HCl
• CAS Number: 122892-31-3
• Poids moléculaire : 394.89
• Numéro MDL: MFCD00881710
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825103
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: H₂O: ≥48 mg/mL
• Auteur: Abbott
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2
• InChI: 1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
• Clé InChI: ZTOUXLLIPWWHSR-UHFFFAOYSA-N

Description

Description générale

Itopride hydrochloride is a new prokinetic drug.

Actions biochimiques/physiologiques

Antagonist of dopamine D2-receptor with anticholinesterase activity.

Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.

Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.

Caractéristiques et avantages

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H410
• Conseils de prudence: P273 - P391 - P501
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable