SML0061

SAHA

≥98% (HPLC), powder, HDAC inhibitor

• Synonyme(s) : N-hydroxy-N′-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat
• Formule empirique (notation de Hill) : C₁₄H₂₀N₂O₃
• CAS Number: 149647-78-9
• Poids moléculaire : 264.32
• Numéro MDL: MFCD00945317
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825127
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: SAHA, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥15 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: ONC(=O)CCCCCCC(=O)Nc1ccccc1
• InChI: 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
• Clé InChI: WAEXFXRVDQXREF-UHFFFAOYSA-N
• Informations sur le gène: human ... HDAC1(3065), HDAC2(3066), HDAC3(8841), HDAC6(10013)

Description

Application

SAHA may be used to study gene regulation, transcription regulation and cell signaling.

Actions biochimiques/physiologiques

Potent, reversible pan-histone deacetylase (HDAC) inhibitor.

SAHA or Vorinostat facilitates the transcription of genes that result in apoptosis, differentiation and growth arrest. It has been observed to give beneficial results in lymphoma but not in solid tumors.

Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs, altering gene transcription and inducing cell cycle arrest and/or apoptosis in a wide variety of transformed cells.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H341,H360
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Muta. 2 - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable