C0621

CI−994

≥98% (HPLC), powder

• Synonyme(s) : 4-Acetylamino-N-(2′-aminophenyl)benzamide, Acetyldinaline, Tacedinaline
• Formule empirique (notation de Hill) : C₁₅H₁₅N₃O₂
• CAS Number: 112522-64-2
• Poids moléculaire : 269.30
• Numéro MDL: MFCD00866266
• Code UNSPSC : 12352200
• ID de substance PubChem : 329774808
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N
• InChI: 1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
• Clé InChI: VAZAPHZUAVEOMC-UHFFFAOYSA-N
• Informations sur le gène: human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

Description

Application

CI-994 has been used:

• as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects
• as an HDAC inhibitor for screening in SPEL cells
• to study its effects on human myeloid and erythroid progenitors

Actions biochimiques/physiologiques

CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.

Orally available HDAC Inhibitor; CI-994 blocks cells in the G1-S phase of the cell cycle.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves