SML0207

SB 328437

≥98% (HPLC)

• Synonyme(s) : L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
• Formule empirique (notation de Hill) : C₂₁H₁₈N₂O₅
• CAS Number: 247580-43-4
• Poids moléculaire : 378.38
• Numéro MDL: MFCD16618397
• Code UNSPSC : 12352202
• ID de substance PubChem : 329825229
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥10 mg/mL
• Auteur: GlaxoSmithKline
• Température de stockage: 2-8°C
• Chaîne SMILES: COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
• InChI: 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• Clé InChI: VMFGCGRAIBLAFY-IBGZPJMESA-N

Description

Application

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

Actions biochimiques/physiologiques

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.

SB-328437 is a CCR3 Antagonist.

SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

Caractéristiques et avantages

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable