SML0293

Telbivudine

≥98% (HPLC)

• Synonyme(s) : β-L-Thymidine, 1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-Pyrimidinedione, 2′-Deoxy-L-thymidine, Epavudine, L-Thymidine, NV 02B, Sebivo
• Formule empirique (notation de Hill) : C₁₀H₁₄N₂O₅
• CAS Number: 3424-98-4
• Poids moléculaire : 242.23
• Numéro MDL: MFCD02683612
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825300
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -15 to -22°, c = 1 in H₂O
• Couleur: white to beige
• Solubilité: H₂O: 10 mg/mL (clear solution)
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=CN([C@@H]2C[C@@H](O)[C@H](CO)O2)C(=O)NC1=O
• InChI: 1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
• Clé InChI: IQFYYKKMVGJFEH-CSMHCCOUSA-N

Description

Application

Telbivudine has been used to explore the mechanisms of telbivudine (LdT) induced creatine kinase (CK) elevation.

Actions biochimiques/physiologiques

Telbivudine is a nucleoside analog that is widely used to treat hepatitis B virus (HBV) infection.

Telbivudine is a synthetic molecule containing β-L-configuration. Telbivudine improves the estimated glomerular filtration rate (eGFR) in response to chronic hepatitis B (CHB). It prevents perinatal transmission and enhances the hepatitis B e antigen (HBeAg) seroconversion. It is also known to cause side effects such as creatine kinase (CK) elevation and fatal rhabdomyolysis.

Telbivudineis a Hepatitis B antiviral agent.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable