SML0430

PR-619

≥95% (HPLC)

• Synonyme(s) : 2,6-Diamino-3,5-dithiocyanopyridine, Thiocyanic acid C,C′-(2,6-diamino-3,5-pyridinediyl) ester; 2,6-Diaminopyridine-3,5-bis(thiocyanate)
• Formule empirique (notation de Hill) : C₇H₅N₅S₂
• CAS Number: 2645-32-1
• Poids moléculaire : 223.28
• Numéro MDL: MFCD00830384
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825425
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL (clear solution)
• Température de stockage: −20°C
• Chaîne SMILES: Nc1nc(N)c(SC#N)cc1SC#N
• InChI: 1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
• Clé InChI: ZXOBLNBVNROVLC-UHFFFAOYSA-N

Description

Application

PR-619 has been used:

• as a component of lysis buffer and also as a deubiquitinase inhibitor to treat proteins derived from SILAC-labeled Jurkat cells
• as a pan-deubiquitinase inhibitor to study its effect on adenoassociated virus (AAV) transduction
• in radioimmunoprecipitation assay buffer (RIPA) buffer used for ubiquitination assays

Actions biochimiques/physiologiques

PR-619 cell permeable, broad spectrum deubiquitylating enzymes (DBUs) inhibitor; general deubiquitylase (DUB) inhibitor.

PR-619 is a cell permeable broad spectrum deubiquitylating enzymes (DBUs) inhibitor. PR-619 induces the accumulation of polyubiquitylated proteins in cells without directly affecting proteasome activity.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3