SML0472

4-IPP

≥97% (HPLC)

• Synonyme(s) : 4-Iodo-6-phenylpyrimidine
• Formule empirique (notation de Hill) : C₁₀H₇IN₂
• CAS Number: 41270-96-6
• Poids moléculaire : 282.08
• Numéro MDL: MFCD00234609
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825428
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 10 mg/mL (clear solution, warmed)
• Température de stockage: −20°C
• Chaîne SMILES: Ic1cc(ncn1)-c2ccccc2
• InChI: 1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
• Clé InChI: ZTCJXHNJVLUUMR-UHFFFAOYSA-N

Description

Application

4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.

Actions biochimiques/physiologiques

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.

4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist.

4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3