SML0671

Nitecapone

≥98% (HPLC)

• Synonyme(s) : 3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione, OR-462
• Formule empirique (notation de Hill) : C₁₂H₁₁NO₆
• CAS Number: 116313-94-1
• Poids moléculaire : 265.22
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: [N+](=O)([O-])c1c(c(cc(c1)C=C(C(=O)C)C(=O)C)O)O
• InChI: 1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3
• Clé InChI: UPMRZALMHVUCIN-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT).

Nitecapone is a short-acting inhibitor of catechol-O-methyltransferase (COMT). Nitecapone displays in vivo activity in peripheral tissues, but does not pentrate the blood brain barrier. The compound increases mechanical and thermal nociception, and reduces neuropathic pain in diabetic rats and in a spinal nerve ligation model.

Caractéristiques et avantages

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable