SML0674

Ramosetron hydrochloride

≥98% (HPLC)

• Synonyme(s) : (R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride, YM-060, YM060
• Formule empirique (notation de Hill) : C₁₇H₁₇N₃O · HCl
• CAS Number: 132907-72-3
• Poids moléculaire : 315.80
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -36 to -46°, c = 1 in methanol
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C
• InChI: 1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
• Clé InChI: XIXYTCLDXQRHJO-RFVHGSKJSA-N

Description

Actions biochimiques/physiologiques

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.

Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.

Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable