SML0773

GSK-650394

≥98% (HPLC)

• Synonyme(s) : 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid, GSK 650394, GSK650394
• Formule empirique (notation de Hill) : C₂₅H₂₂N₂O₂
• CAS Number: 890842-28-1
• Poids moléculaire : 382.45
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: [nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3
• InChI: 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
• Clé InChI: WVSBGSNVCDAMCF-UHFFFAOYSA-N

Description

Application

GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.

Actions biochimiques/physiologiques

GSK-650394 has an IC₅₀ value of 62 nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103 nM for SGK2. It has an ability to stop viral replication at concentrations that are nontoxic to cells.

GSK-650394 is a potent and selective Serum- and glucocorticoid-regulated kinase 1 (SGK1) antagonist.

GSK-650394 is a potent, selective SGK1 antagonist.

Caractéristiques et avantages

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable