E8640

E-64d

powder, ≥98% (TLC)

• Synonyme(s) : (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester, EST
• Formule empirique (notation de Hill) : C₁₇H₃₀N₂O₅
• CAS Number: 88321-09-9
• Poids moléculaire : 342.43
• Numéro MDL: MFCD00132883
• Code UNSPSC : 12352202
• ID de substance PubChem : 24894681
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: E-64d, protease inhibitor
• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥98% (TLC)
• Forme: powder
• Solubilité: methanol: water (1:1): 5 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
• InChI: 1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
• Clé InChI: SRVFFFJZQVENJC-IHRRRGAJSA-N
• Informations sur le gène: human ... CAPN1(823)

Description

Application

E-64d has been used as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7 cells. It has also been used as a protease inhibitor in free calcium physiological tyrode solution for perfusion into the isolated heart samples.

Actions biochimiques/physiologiques

E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B, calpains 1 and 2. E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI) and Alzheimer′s disease (AD). It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves