SML1083

Ethacrynic acid

≥97% (HPLC)

• Synonyme(s) : 2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid, ECA, Etacrynic acid, [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid, (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid
• Formule empirique (notation de Hill) : C₁₃H₁₂Cl₂O₄
• CAS Number: 58-54-8
• Poids moléculaire : 303.14
• Numéro CE : 200-384-1
• Numéro MDL: MFCD00056693
• Code UNSPSC : 12352106
• ID de substance PubChem : 329825461
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
• InChI: 1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
• Clé InChI: AVOLMBLBETYQHX-UHFFFAOYSA-N
• Informations sur le gène: human ... SLC12A1(6557)

Description

Actions biochimiques/physiologiques

Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.

Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable