B2515

L-Buthionine-sulfoximine

≥97% (TLC)

• Synonyme(s) : L-BSO
• Formule empirique (notation de Hill) : C₈H₁₈N₂O₃S
• CAS Number: 83730-53-4
• Poids moléculaire : 222.31
• Beilstein: 2367136
• Numéro MDL: MFCD00067000
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278263
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥97% (TLC)
• Forme: powder
• Pf: 224-226 °C
• Solubilité: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: CCCCS(=N)(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• Clé InChI: KJQFBVYMGADDTQ-CVSPRKDYSA-N
• Informations sur le gène: human ... GCLC(2729), GCLM(2730)

Description

Application

L-Buthionine-sulfoximine has been used:

• as a selective activator for the induction of ferroptosis in rat apoptotic cells
• as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
• as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages

Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Actions biochimiques/physiologiques

Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)