SML1489

FICZ

≥95% (HPLC), lyophilized powder, AhR agonist

• Synonyme(s) : 5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde, 6-Formylindolo[3,2-b]carbazole
• Formule empirique (notation de Hill) : C₁₉H₁₂N₂O
• CAS Number: 172922-91-7
• Poids moléculaire : 284.31
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: FICZ, ≥95% (HPLC)
• Niveau de qualité: 100
• Essai: ≥95% (HPLC)
• Forme: lyophilized powder
• Couleur: yellow
• Solubilité: DMSO: 0.5 mg/mL, clear (warmed)
• Température de stockage: −20°C
• Chaîne SMILES: [nH]1c2c(c5c1cccc5)cc3[nH]c4c(c3c2C=O)cccc4
• InChI: 1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H
• Clé InChI: ZUDXFBWDXVNRKF-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

FICZ (6-formylindolo(3,2b)carbazole) being a photooxidation product of tryptophan, might serve as a chemical messenger of light.

FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.

FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR).

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable