SML1606

Oseltamivir phosphate

≥98% (HPLC)

• Synonyme(s) : GS4104, (3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate salt
• Formule empirique (notation de Hill) : C₁₆H₂₈N₂O₄ ·H₃PO₄
• CAS Number: 204255-11-8
• Poids moléculaire : 410.40
• Numéro MDL: MFCD08059548
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825492
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -26 to -36°, c = 1 in H₂O
• Couleur: white to beige
• Solubilité: H₂O: 30 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: OP(O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1
• InChI: 1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1
• Clé InChI: PGZUMBJQJWIWGJ-ONAKXNSWSA-N

Description

Actions biochimiques/physiologiques

Oseltamivir phosphate is an influenza viral neuraminidase inhibitor. Oseltamivir phosphate, an antiviral, is used clinically to treat influenza A and influenza B, and to prevent flu after exposure. Oseltamivir phosphate is hydrolyzed in the liver to its active form, oseltamivir carboxylate, which is an inhibitor of influenza viral neuraminidases essential for viral replication. Oseltamivir has a broad spectrum of activity against a range of influenza A and B subtypes with IC₅₀ values for neuraminidases measured from less than 1 nM to approximately 30 nM, depending on the virus subtype.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317,H319,H412
• Conseils de prudence: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable