SML2371

FC-99 hydrochloride

≥98% (HPLC)

• Synonyme(s) : FC 99 hydrochloride, FC99 hydrochloride, N1-[(4-Methoxyphenyl)methyl]-4-methyl-1,2-benzenediamine hydrochloride
• Formule empirique (notation de Hill) : C₁₅H₁₈N₂O · xHCl
• CAS Number: 1097810-71-3
• Poids moléculaire : 242.32 (free base basis)
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=CC(N)=C(C=C1)NCC2=CC=C(C=C2)OC
• InChI: 1S/C15H18N2O/c1-11-3-8-15(14(16)9-11)17-10-12-4-6-13(18-2)7-5-12/h3-9,17H,10,16H2,1-2H3
• Clé InChI: ZPNPYWSZYRMBNP-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

FC-99 is a benzenediamine derivative that inhibits LPS-induced IRAK4 phosphorylation/activation and downstream signaling events (5-45 μM; murine RAW 264.7 & peritoneal macrophages), including IRAK1 (a TLR3 pathway negative regulator) degradation, p38/ERK/JNK activation, and cytokines production. FC-99 inhibits RSV replication (50 μM; A549) and poly(I:C)-indued IRF3/IFN-α/JAK/STAT1 signalling in cultures (0.5-50 μM; murine peritoneal macrophages), and ameliorates sepsis induction following caecal ligation puncture (CLP) in mice in vivo (100/70/32.5% motality in 7 days with 0/30/100 mg/kg i.p. 2 h prior to CLP).

FC-99 is known to affect the levels of serum immunoglobulin. It might be therapeutically beneficial in systemic lupus erythematosus.

IRAK4 activation and IRAK1 degradation inhibitor that suppresses toll-like receptors (TLRs) cellular signaling and ameliorates sepsis induction in mice in vivo.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable