SML2428

Pentabromopseudilin

≥97% (HPLC)

• Synonyme(s) : Pentabromopseudilin, 2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol, PBP
• Formule empirique (notation de Hill) : C₁₀H₄Br₅NO
• CAS Number: 10245-81-5
• Poids moléculaire : 553.66
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥97% (HPLC)
• Forme: solid
• Température de stockage: −20°C
• Chaîne SMILES: OC1=C(Br)C=C(Br)C=C1C2=C(Br)C(Br)=C(Br)N2
• InChI: 1S/C10H4Br5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H
• Clé InChI: LXMNWKJHYOZUQL-UHFFFAOYSA-N

Description

Description générale

Pentabromopseudilin (PBP) is a potent antibiotic originally isolated from the marine bacterium Pseudomonas bromoutilis. 2 PBP exhibits cytotoxic, antibacterial and phytotoxic activities, including the inhibition of human 12- and 15-lipoxygenases3 and potent inhibition of myosin-dependent processes. 4-5 PBP was identified as a potent inhibitor of the motor activity of vertebrate myosin V with an IC50 value of 1.2μM. 5 PBP inhibits the ATPase activity of myosin by increasing its affinity for ADP, reducing ATP-binding and hydrolysis rates, and through coupling between actin and nucleotide-binding sites in the motor domain. 4 Recently, it was also demonstrated that PBP suppresses TGF-β activity.

Autres remarques

Solubility: Chloroform/dichloromethane (at least 10 mg/ml), methanol/ethanol (at least 1 mg/ml), DMSO (10mM)
Working Stock: PBP can be dissolved in DMSO at concentration of 10mM, solution should be stored in the dark at -80°C.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable