T1001

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

• Synonyme(s) : Globulins thyro, Thyractin
• CAS Number: 9010-34-8
• Numéro CE : 232-721-3
• Numéro MDL: MFCD00132429
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: bovine thyroid
• Essai: ≥90% (agarose gel electrophoresis)
• Forme: powder
• Poids mol.: ~670 kDa
• Composition: Iodine, ≥0.20%
• Dosage de l'azote: 13.0-16.0% total
• Cendres: ≤4%
• Solubilité: H₂O: 20 mg/mL
• Numéro d'accès UniProt: P01267
• Température de stockage: −20°C
• Informations sur le gène: cow ... TG(280706)

Description

Application

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.

Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Actions biochimiques/physiologiques

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)