T2320

T0901317

≥98%

• Synonyme(s) : N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
• Formule empirique (notation de Hill) : C₁₇H₁₂NSO₃F₉
• CAS Number: 293754-55-9
• Poids moléculaire : 481.33
• Numéro MDL: MFCD03412028
• Code UNSPSC : 12352106
• ID de substance PubChem : 24900032
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 200
• Essai: ≥98%
• Poids mol.: 481.3
• Température de stockage: −20°C
• Chaîne SMILES: OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
• Clé InChI: SGIWFELWJPNFDH-UHFFFAOYSA-N
• Informations sur le gène: human ... ABCA1(19), NR1H2(7376), NR1H3(10062)

Description

Application

T0901317 has been used in LXR agonist study in order to observe the expression of all dietary cholesterol-regulated genes in mice. It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.

Actions biochimiques/physiologiques

LXR agonist whose treatment results in an LXR-dependent up-regulation of ABC1 gene expression

T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)