T5575

TG003

≥98% (HPLC)

• Synonyme(s) : (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
• Formule empirique (notation de Hill) : C₁₃H₁₅NO₂S
• CAS Number: 300801-52-9
• Poids moléculaire : 249.33
• Numéro MDL: MFCD00624584
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278611
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Pf: 132-132.5 °C
• Solubilité: DMSO: 33 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
• InChI: 1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
• Clé InChI: BGVLELSCIHASRV-QPEQYQDCSA-N

Description

Application

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

TG003 has been used to develop assays for screening substances that affect mRNA splicing¹.

Actions biochimiques/physiologiques

Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). K_i = 10 nM for mClk1/Sty; IC₅₀ = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.

TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

Conditionnement

Packaged under nitrogen.

Notes préparatoires

TG003 is soluble in DMSO at 33 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves