S4068

Splitomicin

≥98% (HPLC), powder

• Synonyme(s) : 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
• Formule empirique (notation de Hill) : C₁₃H₁₀O₂
• CAS Number: 5690-03-9
• Poids moléculaire : 198.22
• Numéro MDL: MFCD08705254
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724608
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1CCc2c(O1)ccc3ccccc23
• InChI: 1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
• Clé InChI: ISFPDBUKMJDAJH-UHFFFAOYSA-N

Description

Application

Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells and sirtuins in human breast cancer cells. Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies.

Actions biochimiques/physiologiques

Sir2p (silent information regulator) and HDAC inhibitor.

Splitomicin, a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). It inhibits the NAD⁺-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca⁺² and ATP release. This results in inhibition of platelet aggregation that is effective in cardiovascular and cerebrovascular diseases.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)