T6330

THI

• Synonyme(s) : 2-ATHBI, 2-Acetyl-4-tetrahydroxybutyl Imidazole; 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone
• Formule empirique (notation de Hill) : C₉H₁₄N₂O₅
• CAS Number: 94944-70-4
• Poids moléculaire : 230.22
• Numéro MDL: MFCD08752516
• Code UNSPSC : 12352211
• ID de substance PubChem : 329826636
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Couleur: white to light brown
• Solubilité: DMSO: 2 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI: 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
• Clé InChI: CQSIXFHVGKMLGQ-BWZBUEFSSA-N

Description

Actions biochimiques/physiologiques

2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation.

THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant.

THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

Notes préparatoires

THI is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable