T7040

Tyrphostin 1

≥98%

• Synonyme(s) : (4-Methoxybenzylidene)malononitrile
• Formule linéaire : CH₃OC₆H₄CH=C(CN)₂
• CAS Number: 2826-26-8
• Poids moléculaire : 184.19
• Numéro MDL: MFCD00019787
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278751
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Essai: ≥98%
• Forme: solid
• Puissance: >1250 μM IC₅₀ (negative control)
• Pf: 113-116 °C (lit.)
• Solubilité: chloroform: soluble 50 mg/mL, clear, light yellow; DMSO: soluble
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc(cc1)\C=C(/C#N)C#N
• InChI: 1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
• Clé InChI: UOHFCPXBKJPCAD-UHFFFAOYSA-N
• Informations sur le gène: human ... EGFR(1956)

Description

Application

Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.

Actions biochimiques/physiologiques

EGFR tyrosine kinase inhibitor.

Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca²⁺ channels and inhibit growth in vascular smooth muscle cells,.

Caractéristiques et avantages

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Notes préparatoires

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)