T7165

Tyrphostin 23

≥98%

• Synonyme(s) : (3,4-Dihydroxybenzylidene)malononitrile, RG-50810
• Formule empirique (notation de Hill) : C₁₀H₆N₂O₂
• CAS Number: 118409-57-7
• Poids moléculaire : 186.17
• Numéro MDL: MFCD00133899
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278041
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Essai: ≥98%
• Forme: powder
• Puissance: 35 μM IC₅₀
• Solubilité: DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: Oc1ccc(cc1O)\C=C(\C#N)C#N
• InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• Clé InChI: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• Informations sur le gène: human ... CDK2(1017)

Description

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Actions biochimiques/physiologiques

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)