U4133

URB597

≥98% (HPLC), powder

• Synonyme(s) : Cyclohexylcarbamic acid 3´-carbamoyl-biphenyl-3-yl ester
• Formule empirique (notation de Hill) : C₂₀H₂₂N₂O₃
• CAS Number: 546141-08-6
• Poids moléculaire : 338.40
• Numéro MDL: MFCD05863934
• Code UNSPSC : 12352200
• ID de substance PubChem : 329827629
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: DMSO: soluble ~14 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: NC(=O)c1cccc(c1)-c2cccc(OC(=O)NC3CCCCC3)c2
• InChI: 1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
• Clé InChI: ROFVXGGUISEHAM-UHFFFAOYSA-N

Description

Description générale

URB597 binds to active sites of fatty acid amide hydrolases and inhibits their activity. URB597 alters expression of tyrosine hydroxylase and interacts with abnormal-cannabidiol (Abn-CBD) and peroxisome proliferator-activated receptors (PPARs). URB597 elicits antinociception property via cannabinoid receptor by maintaining endocannabinoid anandamide (AEA) levels. URB597 reduces abnormal hyperactivity in neurons and could be for treatment of seizures and improving synaptic plasticity.

Actions biochimiques/physiologiques

Potent, selective fatty acid amide hydrolase (FAAH) inhibitor.

Notes préparatoires

URB597 is soluble in DMSO at a concentration that is approximately 14 mg/ml.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves