Y102

YC-1

powder

• Synonyme(s) : 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole
• Formule empirique (notation de Hill) : C₁₉H₁₆N₂O₂
• CAS Number: 170632-47-0
• Poids moléculaire : 304.34
• Numéro MDL: MFCD06407798
• Code UNSPSC : 41106305
• ID de substance PubChem : 24278782
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 200
• Couleur: white to yellow
• Solubilité: DMSO: 10 mg/mL; H₂O: insoluble
• Chaîne SMILES: OCc1ccc(o1)-c2nn(Cc3ccccc3)c4ccccc24
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• Clé InChI: OQQVFCKUDYMWGV-UHFFFAOYSA-N
• Informations sur le gène: human ... PDE5A(8654)

Description

Application

YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:

• to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
• to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
• to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.

Actions biochimiques/physiologiques

NO (nitric oxide)-independent activator of soluble guanylyl cyclase.

YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)